RRM1 and lung carcinoma: More recently, an international phase III trial that utilized levels of RRM1 to assign lung cancer patients to a gemcitabine-containing regimen if RRM1 levels were low and a docetaxel-containing regimen if RRM1 levels were high versus a control arm of unselected chemotherapy consisting of carboplatin plus gemcitabine, did not demonstrate a survival or response rate benefit from individualizing therapy [43].