It is now well documented that while some glioma cell lines are sensitive to the apoptotic effects of TRAIL, the majority of glioma cell lines and patient samples are resistant [19, 22, 40]; therefore, combinatorial approaches with conventional chemotherapies or novel targeted therapies may be required to ensure the therapeutic potential of TRAIL in GBM treatment is fully exploited [19]. The gene discussed is TNFSF10; the disease is central nervous system cancer.