The activation of MET can promote epithelial-mesenchymal transition and tumor invasiveness [49,50], partly by increasing the activity of transcriptional repressors, such as snail homolog 1 (SNAI1; also known as SNAIL), ZEB1 and TWIST1, that reduce E-cadherin expression, increase N-cadherin expression and turn on the expression of other mesenchymal markers [51]. The gene discussed is TWIST1; the disease is neoplasm.