On the other hand, another study by Jin et al. showed that ADAMTS18 is frequently hypermethylated in tumors and overexpression of wild-type ADAMTS18 inhibits both anchorage-independent and -dependent nasopharyngeal and esophageal carcinoma cell growth using monolayer colony formation and soft agar assays, indicating a tumor suppressor role of this gene [205]. This evidence concerns the gene ADAMTS18 and neoplasm.