It is also interesting to note that even though these 10 ADAMTS—ADAMTS1, ADAMTS2, ADAMTS4, ADAMTS5, ADAMTS8, ADAMTS9, ADAMTS12, ADAMTS13, ADAMTS15, and ADAMTS18 have emerged as important players in angiogenesis and/or cancer, their mechanisms of action are not shared by all family members. This evidence concerns the gene ADAMTS2 and cancer.