Currently, the pathways in Reactome cover about 25% of the gene products encoded in the human genome, and contain the normal versions of many pathways that can be abnormally activated in cancer, such as “Signaling by EGFR” [21], “Signaling by FGFR” [22], “Signaling by NOTCH” [23], “PIP3 Activates AKT Signaling” [24], “RAF/MAP Kinase Cascade” [25]. The gene discussed is EGFR; the disease is cancer.