For instance, MLL-AF4 fusions are predominantly found in ALL (although also detected in biphenotypic ALL, therapy related AML and rare cases of AML), MLL-ELL, MLL-AF10 and MLL-AF6 fusions are predominantly present in AML, while MLL-AF9 and MLL-ENL are found in both AML and ALL (although rare in adult ALL, reviewed in [121,122,142]). Here, AFF1 is linked to acute lymphoblastic leukemia.