While there are numerous sequelae to these initial changes induced by PEGPH20 alone, it is now clear that these changes alone can result in inhibition of tumor cell DNA synthesis, and reduction in the expression of collagen (collagen 1-alpha-1 [Col1α1]; collagen 5-alpha-1 [Col5α1]) and tenascin-C (TNC) (Figure 7) [13], none of which directly interacts with HA. This evidence concerns the gene TNC and neoplasm.