AKT1 and central nervous system cancer: Several micro-RNAs have been shown to regulate PI3K/AKT pathway in gliomas such as oncogenic miR-21 and miR-26a, miR-221/222 as activators of AKT, and miR-451 and miR-128 as negative regulators of AKT pathway [149,150,151,152,153,154,155].