VDR and neoplasm: For example, high loadings of CYP27B1 and VDR as well as of COX-2 on Factor 1TU (Table 1) indicate that (i) 25-hydroxyvitamin D-1α-hydroxylase-mediated synthesis of 1,25-(OH)2D3 and its genomic actions via the nuclear VDR are apparently not disrupted in colorectal tissue irrespective of subsite, age, gender, and tumor grading, and (ii) that expression of the 1,25-(OH)2D3/VDR system and of the inflammation marker COX-2 are strongly correlated.