MMP14 and acute myeloid leukemia: Moreover, when we exposed conditioned media from co-cultures of AML cells and fibroblasts to EGCG, an inhibitor of MT1-MMP and other MMPs [31], we observed a decrease in the level of proMMP-9 and proMMP-2 as well as a dose-dependent (from 1 to 50 μM of EGCG) reduction of proMMP-2 activation (Figure 2D).