TGFβRII expression in CAFs is absent in human cancer bone metastases [93] and prostate cancer cells in vitro are able to suppress TGFβRII, smooth muscle actin and ECM production, and increase vimentin, integrins, MMP9 and MMP14 in bone marrow stroma cells [94] resulting in the formation of a more fibroblast like than myofibroblast-like stroma. This evidence concerns the gene VIM and cancer.