The neuroendocrine tumors arising from pancreatic islet cells could be non-functioning (NF) characterized by variable production and release of neuroendocrine polypeptides without a specific syndrome and often showing a malignant course, or functioning with production of active hormones such as gastrin, insulin, vasoactive intestinal polypeptide (VIP), glucagon, and somatostatin leading to a clinical syndrome [9,10]. Here, VIP is linked to neuroendocrine neoplasm.