This immunosuppression was thought to be induced by the chronic inflammation characterized by the accumulation of inflammatory mediators (cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins) as well as immunosuppressive leucocytes like CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs), CD4+CD25+Foxp3+ regulatory T cells, M2 subset of macrophages, etc. in tumor bearing hosts [33,34,35,36]. This evidence concerns the gene CD4 and neoplasm.