Finally, we concluded that melatonin, and perhaps other antioxidants such as silibinin which also induce differentiation of prostate cancer cells, which do not increase apoptosis, but still inhibit NFκB activation, do not increase cell death because they are increasing endogenous antioxidants such as antioxidant enzymes or GSH [130]. Here, NFKB1 is linked to Familial prostate cancer.