Other mechanisms for aborogating the imune system by tumor cells include local production of cytokines such as vascular endothelial growth factor (VEGF), interleukins-6, 8 and 10 (IL-6, IL-8, IL-10), and tumor growth factor beta (TGF-beta), which create a tolerogenic phenotype in antigen presenting cells and allow tumor cells to avoid detection by various facets of the immune system. This evidence concerns the gene CXCL8 and neoplasm.