TNFSF10 and hepatocellular carcinoma: Yamanaka et al. showed for the first time that HCC cell lines were significantly sensitized to TRAIL-induced apoptosis by chemotherapeutic agents that induce DNA damage, in particular, doxorubicin (topoisomerase II inhibitor), camptothecin (topoisomerase I inhibitor), 5-fluorouracil (5-FU).