CDH1 and gastrin-producing neuroendocrine tumor: When we analyzed the different entities, we found loss of E-cadherin in only 7/26 (27%) benign insulinomas, but in three of four metastatic insulinomas, in 29/43 (67%) NF-PETs, and in 8/21 (38%) gastrinomas (see Figure 1 A–C and Figure 2 A,B).