Next we stained for the E-cadherin opponents Snail and Twist and found expression of Snail in 16/26 (61%) benign insulinomas, in all four metastatic insulinomas, in 24/43 (55%) NF-PETs, and in 13/21 (62%) gastrinomas. This evidence concerns the gene TWIST1 and gastrin-producing neuroendocrine tumor.