Combined therapy comprising intra-arterial infusion of 5-FU and systemic interferon-α (IFN-α) (FAIT) has been reported to be useful as a palliative treatment for HCC patients with major vascular invasion, although monotherapy with IFN-α had minimal objective response rate against HCC [35,36,37]. This evidence concerns the gene IFNA1 and hepatocellular carcinoma.