CCL2 and neoplasm: These three chemokines are classified as potent tumor-promoting chemokines in a very large number of malignancies, and their roles include, between others: Induction of high presence of Tumor-Associated Macrophages (TAM) in tumors (CCL2, CCL5); Elevation of angiogenesis (CCL2 and CXCL8); and induction of tumor cell migration and proliferation (CCL5, CXCL8) [5,6,7,8,9,10,11,12,13,14].