IL1B and neoplasm: Specifically, we have identified Tumor Necrosis Factor α (TNFα) and Interleukin 1β (IL-1β)—two inflammatory mediators that are known to be of a tumor-promoting phenotype [24,25,26,27,28,29]—as potent chemokine inducers in the present cell system, and revealed that their effects were significantly higher than those obtained by the oncogenic alterations of Ras and p53 combined.