NF-kappaB exerts its metastasis-promoting effect by regulating the transcription of a subset of genes known to be important for tumor metastasis, such as prometastatic matrix metalloproteinase 9 (MMP9), a urokinase-like plasminogen activator (uPA), which is MMP9 activator, and heparanase. Here, MMP9 is linked to neoplasm.