Constitutive expression of LIN28B in colon cancer cell lines turns on colonic stem cell markers PROM1 and LGR5 and enhances the metastatic capacity of these cancer cells in a mouse model [61] The effects of LIN28B in this model appears to be driven in part by the enhanced invasiveness and motility of LIN28B-overexpressing tumor cells. The gene discussed is PROM1; the disease is malignant colon neoplasm.