HSPA1A and chronic myelogenous leukemia, BCR-ABL1 positive: Indeed, chronic myeloid leukemia (CML) cells that express BCR-ABL oncogenic kinase exhibit increased levels of hyperphosphorylated HSF1, inducible Hsp70 and anti-apoptotic Mcl-1 proteins, while cells in which BCR-ABL is inhibited have less Hsp70, and the activation of pro-apoptotic Bax induced by imatinib leads to cell death [181].