PTGER4 and familial pancreatic carcinoma: PGE2 may also induces cell migration and invasion by upregulation of matrix metalloproteinase 2 (MMP2) via an ERK-ETS1 cascade in pancreatic cancer cell lines [89] and upregulation of CCR7 via PTGER2 (EP2) and PTGER4 (EP4) in breast cancer cell lines [90].