For example, the FDA has approved two monoclonal antibodies (cetuximab and panitumumab), which target EGFR, for treatment of patients with metastatic CRC and two EGFR tyrosine kinase inhibitors (gefitinib and erlotinib) for treatment of patients with metastatic non-small cell lung cancer. This evidence concerns the gene EGFR and non-small cell lung carcinoma.