IL10 and neoplasm: IL-12 appears to have the potent ability to induce counterregulatory cytokines such as IL-10 that may abrogate its immunostimulatory properties, depending on the dose and schedule of administration, but it may have promise as a component of the immune adjuvant in certain tumor vaccine strategies as well as in locoregional delivery vehicles such as plasmid electroporation [131,132].