This study also showed that treatment of MYCN-amplified and therapy-resistant neuroblastomas with an oligonucleotide designed to block the action of miR-17-5p, a miR-17-5p antagomir, abolishes the p21 and BIM upregulation, inhibits cell cycle progression and promotes apoptosis [132]. This evidence concerns the gene BCL2L11 and neuroblastoma.