A positive significant correlation between MVD and α-SMA expression in the CT and P region compared to the M region of GITC was similar to the findings in breast in situ carcinoma [50], suggesting that in those regions a proportion of blood vessels are mature and might contribute to the gastrointestinal tumor angiogenesis and the vascular remodelation. The gene discussed is ACTA1; the disease is lobular breast carcinoma in situ.