Taken together these results suggest that MVD, VEGF and vascular maturity are related as important factors involved in gastrointestinal tumor biology, which suggest that future research should focus on different regions of the tumor, not only into the morphofunctional aspects of endothelial cells, but in the maturity of blood vessels through the presence of periendothelial cells, as possible targets of vascular therapy. Here, VEGFA is linked to digestive system neoplasm.