TNFRSF8 and anaplastic large cell lymphoma: The addition of one of these anti-mitotic agents, auristatin E, to a chimeric (human/mouse) IgG1 antibody directed against CD30 (brentuximab) led to the generation of brentuximab vedotin (or SGN-35), an antibody-drug conjugate (ADC) significantly more potent than the mAb alone for the treatment of refractory systemic anaplastic large cell lymphoma (ALCL).