PIK3CA and glioblastoma: To date, lots of PI3K inhibitors (many of them are PI3K/mTOR dual inhibitors) such as XL147, XL765 (Exelixis and Sanofi-Aventis), BKM120, BEZ235, BGT226 (Novartis), GDC0980 (Genentech), PKI587, PF04691502 (Pfizer), GSK2126458 (Glaxo-Smith-Kline) are currently undergoing Phase I/II trials for GBM patients.