In the same way that binding of MUC1 to ICAM-1 is inhibited by a MAb to the MUC1-N peptide core [104], natural or induced abs to it could prevent adhesion of cancer cells to ICAM-1 on the cell surface of fibroblasts and endothelial cells, impeding migration of cancer cells away from the tumor and into the circulation. This evidence concerns the gene ICAM1 and cancer.