Elevated IGF-1R expression has been linked to IGF1R amplification, which infrequently occurs in wild-type (WT) gastrointestinal stromal tumors (GIST) that lack prototypical gain-of-function c-kit receptor mutations [22], but over-expression is the norm in pediatric WT GISTs even in the absence of such amplification events [86]. The gene discussed is IGF1R; the disease is gastrointestinal stromal tumor.