IGF1R and sarcoma: The inner workings of the IGF-1R molecular machinery share considerable similarities between carcinomas and sarcomas, both from a myopic view at the level of biologically conserved protein-protein interactions that can be understood with reasonable specificity, and from the higher vantage point of a ‘signaling network’ that can be anticipated to progress, if not deterministically, at least under stochastic rules gleaned from years of scientific scrutiny.