The indole DIM can synergistically inhibit growth of Her2-expressing breast cancer cells [115] through cell-cycle arrest and induction of cell death, in combination with paclitaxel, by modulating Her2-mediated cellular signaling that involves ERK1/2 which demonstrates that DIM may potentially be a beneficial addition to a traditional (taxane-based) chemotherapy regimen. The gene discussed is ERBB2; the disease is breast carcinoma.