Our microarray gene profiling analysis identified survivin as a gene down-regulated by DIM-treatment and we found that down-regulation of survivin by small interfering RNA prior to DIM treatment, in breast cancer cells, resulted in increased cell growth inhibition and apoptosis, whereas over-expression of survivin by cDNA transfection abrogated DIM-induced cell growth inhibition and apoptosis [34]. The gene discussed is BIRC5; the disease is breast cancer.