EGFR and familial pancreatic carcinoma: Further, in an interesting report detailing the role of microRNAs (miRNAs) in DIM-mediated inhibition of pancreatic cancer cells, it has been shown that treatment with DIM leads to up-regulation of miR-146a expression resulting in down-regulation of EGFR and NF-κB which leads to inhibition of pancreatic cancer cell aggressiveness [85].