Tumor-associated macrophages (TAM) derive mostly from circulating monocytes which are attracted into tumor sites, by locally produced chemotactic factors, such as CCL2, CCL5, CCL7, CCL8, CXCL12, vascular endothelial growth factor (VEGF), and macrophage colony stimulating factor (M-CSF) [3]. Here, CXCL12 is linked to neoplasm.