CD8A and colorectal cancer: They analyzed the presence of CD3+, CD8+ infiltration and the expression of granzyme B and its prognostic significance in 215 colorectal cancer patients and found that intra-epithelial infiltration of CD3+ and CD8+ T lymphocytes and stromal infiltration of CD3+ lymphocytes had a major impact on the patients' overall survival in the univariate analysis, independent of their association with MSI-status.