Activation of p38 was associated with induction of autophagy by polygonatum cyrtonema lectin (PCL) in human melanoma cells [120], MCP-1 (monocyte chemotactic protein-1) in cardiomyoblast [121], silibinin in fibrosarcoma cells [122], bromelain in breast cancer cells [123], oridonin in HeLa cells [124] and resveratrol in hepatocellular carcinoma cells [125]. This evidence concerns the gene CCL2 and melanoma.