CD4 and neoplasm: They include approaches aimed at upregulating leukocyte adhesion molecules, potentiating neutrophil and macrophage recruitment or inducing secondary cytokines, activating dendritic cells, CD4+ helper T-lymphocytes, B lymphocytes and natural killer cells, sensitizing CD8+ cytotoxic T-lymphocytes, downregulating CD4+CD25+ T-regulatory cells and inactivating tumor cells through the so-called adaptative immunity [69].