Tumor-cell vaccines have at least three advantages over the single-target approaches in terms of eliciting an immune response: Different and unknown antigens can be targeted at the same time, the immune response is not HLA-restricted, the variety of both MHC class I and class II epitopes processed is likely to be able to stimulate both an innate (natural killer cells, macrophages, and eosinophils) and adaptive (CD8+ and CD4+ T cells) response. This evidence concerns the gene CD4 and neoplasm.