Since testis is an immune privileged site that does not express MHC class I or II molecules [12], these antigens can practically be regarded as tumor-specific and are highly desirable as targets for antigen-specific immunotherapy; (2) Differentiation antigens: Differentiation antigens are tyrosinase, TRP-1, TRP-2, gp100, MART-1, CD20, epithelial cell adhesion molecule (EpCAM) and MC1R [13,14]. The gene discussed is EPCAM; the disease is neoplasm.