SCD and cancer: SCD1 appears to modulate multiple pathways and cascades in cancer cells, including fatty acid biosynthesis through the regulation of ACC, either by allosteric and/or AMPK-mediated mechanisms; glycerolipid formation, likely through the enhanced production of MUFA substrates to the acyltransferases; and the Akt signaling pathway, potentially by affecting the activation status of signaling proteins belonging to this pathway.