IGF1R and hepatocellular carcinoma: However, alterations in key molecular pathways such as WNT/β-catenin, hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met), vascular endothelial growth factor (VEGF), insulin like growth factor receptor (IGF1R) and epidermal growth factor receptor (EGFR) are common to HCC development [4-6].