As mentioned above, ErbB3 and ErbB2 are induced in HCC together with EGFR [52,53], in these conditions the formation of ErbB3/ErbB2, ErbB3/EGFR and ErbB2/EGFR heterodimers could be favored and could participate in transformation. This evidence concerns the gene ERBB3 and hepatocellular carcinoma.