Recently, Yoshikawa et al. [29] demonstrated EGFR, VEGF and human epidermal growth factor receptor (HER) 2 overexpression in 27.4, 53.8 and 0.9% cases of intrahepatic cholangiocarcinoma, and in 19.2, 59.2 and 8.5% of cases of extrahepatic cholangiocarcinoma, respectively. Here, EGFR is linked to intrahepatic cholangiocarcinoma.