IFNG and neoplasm: Collectively, it has been suggested that prognosis in patients with cancer is positively affected by (a) the presence of a tumor gene signature consistent with a type I adaptive immune response (i.e., increased antigen presentation, IFN-γ signaling, and T cell receptor signaling), and (b) the presence of T cells that penetrate through tumor stroma and deeply infiltrate the parenchyma to become intra-tumoral T cells.