This phenotype is also present in about 3% of CRCs occurring in patients with a germline mutation in one of the MMR genes (hMLH1, hMSH2, hMSH6, and PMS2), having hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome) [29-33]. This evidence concerns the gene MSH6 and hereditary nonpolyposis colon cancer.