PROM1 and neoplasm: In a study by Díaz-Miqueli and coworkers [62] using U187 human glioma tumor xenografts in nude mice, both Nimotuzumab and Cetuximab, in spite of their differences in cytotoxicity, induced a reduction in radioresistant CD133+ tumor stem cells, impairing tumor growth progression without producing a tumor shrinkage.