EGFR and non-small cell lung carcinoma: On the other hand, Akashi and coworkers reported that the in vitro and in vivo effect of Nimotuzumab combined with radiation on human NSCLC cell lines correlated with the level of EGFR expression [56], and in a recent report of a phase II clinical trial, a significant survival improvement was observed for patients with EGFR-positive tumors that were treated with Nimotuzumab [33].