Although there was no statistically significant differences between the genotype distribution of EGFR 8227G>A polymorphism and cancer histology within the male population, in female population, ORs for 8227G>A were significantly increased in AC subtype (OR for G/A genotype 1.23, 95% CI 0.87–1.75; OR for A/A genotype 3.52, 95% CI 1.32–9.37), but not that in SCC. This evidence concerns the gene EGFR and cancer.