In addition to the cells with a naturally occurring (-like) phenotype the induced Tr1 and Th3 forms have to be analyzed more specifically since the CRC microenvironment contains high levels of several of the “ingredients” (e.g., IL-6, PGE2, TGF-β) needed for a successful conversion of Tconvs into iTregs. This evidence concerns the gene TGFB1 and colorectal carcinoma.