This too has had limited success, which is highlighted in our studies using BAY-11-7082 (inhibitor of IκB phosphorylation), where AML-derived cell lines HL60, THP-1 and U937 revealed that inhibiting NF-κB had little effect on inducing apoptosis in these AML cells lines and primary samples [17,55]. Here, NFKB1 is linked to acute myeloid leukemia.