HMOX1 and chronic myelogenous leukemia, BCR-ABL1 positive: With regards to Nrf2 in CML, Bonovolias et al. have recently shown that Nrf2-regulated genes can counteract imatinib-induced apoptosis [60], Moreover a number of studies have revealed that HO-1 provides resistance to imatinib and other CML targeted drugs and that silencing HO-1 removes the resistant nature of these cells [70,71].