Based on these findings, it would be worthwhile to examine the endogenous nuclear localization of MAT1A and MAT2A-encoded proteins in HCC cells and understand whether intra-nuclear levels of these proteins in HCC affects the nuclear AdoMet levels and whether this is associated with changes in histone or DNA methylation that could influence HCC development. The gene discussed is MAT1A; the disease is hepatocellular carcinoma.