In lung cancer these include the lysine acetyltransferases KAT13D (Clock) [126], KAT5 (Tip60) [127], KAT2B (PCAF) [128] and KAT13B (SRC-3) [88] (Table 3, Figure 1), while SIRT-1 expression has been linked to cisplatin resistance in epidermoid and hepatoma cells [129]. The gene discussed is CLOCK; the disease is hepatocellular carcinoma.