Polymorphisms and haplotypes associated with a reduced risk of NSCLC have been found in KMT6 (EZH2) and KMT8 (RIZ1) [91,92], while in contrast, polymorphisms in KMT1B (SUV39H2) are associated with an increased lung cancer risk (Table 2) [93]. The gene discussed is EZH2; the disease is lung cancer.