ZEB1 is also a master regulator of the epithelial-mesenchymal transition (EMT) and reports have demonstrated that ZEB1 is important for this process in lung cancer through its regulation of many EMT genes including E-cadherin [163-165], and knockdown of ZEB1 results in the suppression of anchorage-independent cell growth of lung cancer cells [166]. The gene discussed is CDH1; the disease is lung carcinoma.