In NSCLC cell lines, the SWI/SNF complex has been found to form a larger complex containing neuron-restrictive silencer factor (NRSF) and its co-repressors, mSin3A and CoREST and it has been suggested that deregulation of NRSF-regulated genes in NSCLC could in fact contribute to enhanced tumorigenicity [69,70,73]. The gene discussed is SMARCA1; the disease is non-small cell lung carcinoma.