Of these, KMT1C (G9a) when expressed in NSCLC cells causes an aggressive phenotype promoting both invasion and metastasis by silencing expression of the cell adhesion molecule Ep-CAM [94], while overexpression of KMT6 (EZH2) has also been linked to both poor prognosis and cancer aggressiveness in NSCLC [95]. The gene discussed is EZH2; the disease is cancer.