The Class I members comprise HDACs 1-3 and HDAC8, and in NSCLC, elevated levels of HDAC1 mRNA are found in higher stage (Stage III or IV) cancers [69,70,73], while other members of the class I HDACs have also been observed to have altered expression (Table 2, Figure 1) [69,70,73]. Here, HDAC1 is linked to non-small cell lung carcinoma.