In this context, Dai et al. have shown that HSF1 deficiency dramatically reduces spontaneous tumor formation in mice carrying a common, dominant-negative mutation of the p53 gene, whereas Hsf1+/+ and Hsf1+/− mice bearing dominant-negative mutation of p53 develop a broad spectrum of tumor types (sarcomas, lymphoma, carcinomas; [10]). This evidence concerns the gene HSF1 and carcinoma.