The oncogenesis of hereditary CRC cancers is believed to involve four signal transduction pathways: (a) the APC-β-catenin-TCF-myc (Wnt) pathway; (b) the microsatellite unstable pathway; (c) the p53 pathway; and (d) the estrogen receptor hypermethylation pathway [79,80]. This evidence concerns the gene TP53 and colorectal carcinoma.