In regard to chemotherapy design, two approaches are currently used: (1) classical drug synthesis based on the empirical chemopreventive/antineoplastic effect of certain compounds, often with natural origin (e.g., retinoic acid, a natural derivative of vitamin A) and (2) cell death-inducing agents designed with a focus on specific molecular targets with relevance on tumor cell survival (e.g., inhibitors of anti-apoptotic Bcl-2 family members). Here, BCL2 is linked to neoplasm.