The previously mentioned “rheostat model” [38] supports the importance of down-regulating anti-apoptotic Bcl-2 family members (i.e., Bcl-2, Bcl-XL, Bcl-W, Mcl-1, Bcl-2A1, and Bcl-B) to promote apoptotic tumor cell death. The gene discussed is BCL2; the disease is neoplasm.