According to their results, Nutlin bound to MDM2 in the p53-binding pocket and blocked the interaction between MDM2 and p53, which resulted in the stabilization of p53 and also activation of p53-mediated pro-apoptotic pathway in cancer cells bearing wild-type p53. In addition to Nutlin, it has been shown that M1-219, which acts as an inhibitor for MDM2, might be one of the promising agents to reactivate p53 [131]. Here, TP53 is linked to cancer.