EGFR and malignant colon neoplasm: Using H508 human colon cancer cells with high-level expression of CHRM3 [42] we identified bile acids as CHRM3 agonists and revealed that, as with ACh [43], proliferative actions of bile acids require cross-talk between CHRM3 and epidermal growth factor receptors (EGFR) and post-receptor ERK1/2 activation [44,45].